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GLP-1-based therapies have been studied in large-scale clinical trials, with participants seeing average weight reductions of 15% to over 20% of their starting body weight when combined with lifestyle changes

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Retatrutide may be an option for adults with overweight or obesity who have not met their goals with lifestyle changes

Results Construct of the fusion proteins Several flexible and rigid linkers were examined to select the top linker that maintains the functioning of the standard structure of the two domains of the fusion proteins (data not shown)